The 2016 Symposium of Animal Vaccine Development Center

Development of Mycoplasma hyorhinis subunit vaccine - Dose selection

CY Wu, WY Liu, ZY Yang, WC Huang, HJ Lin, JP Wang, JH Lin, ZW Chen, CW Hsu

The disease of respiratory tract is one of major problems that seriously impact the pig industry. Previous studies indicated that Mycoplasma hyopneumoniae was the only pathogen of swine enzootic pneumonia (SEP). Recently, M. hyorhinis was also found to elicit SEP, and caused polyserositis and arthritis in pigs. Pigs infected with M. hyopneumoniae or M. hyorhinis show high morbidity and low mortality, and cause serious economic losses. In this study, subunit vaccines prepared from 3 antigens were used to test the optimal concentration against the M. hyorhinis challenge. After vaccination, average daily weight gain, antibody titer, pathological scores and incidence of disease were used for analysis. The optimal concentration of subunit vaccine showed good efficacy against M. hyorhinis challenge. Further large-scale field trials will be tested to confirm the M. hyorhinis subunit vaccine.