The 2014 Symposium of Animal Vaccine Development Center

Efficacy test of inactivated Actinobacillus pleuropneumoniae vaccine in pigs

JC Hung, ZY Yang, CS Chang, KM Huang, JH Lin, ZW Chen, HH Wu

This study is to compare the efficacy of inactivated Actinobacillus pleuropneumoniae (APP) vaccines. Different combinations of bacterin were prepared from four serotypes of APP and three adjuvants. Each serotype contained 1 × 10^9 CFU/2 mL. Efficacy tests were carried out on pigs. Serotype 1 of live APP, containing 1.38 × 10^3 CFU was used for the challenge test. Five days post-challenge, the control pigs all died and the immunized pigs all survived and recovered. During the immunization period, there were no significant differences between control and immunized pigs in average daily weight gain, body temperature, survival rate and lung lesions. Although the immunized pigs were infected with APP following challenge, the APP bacterin reduced the severity of the lung lesions and increased the survival rate of the pigs.